PDF | The purpose of writing this review on chronotherapeutic drug delivery systems (ChrDDs) is to review the literatures with special focus on ChrDDs and the. Recent advances in chronotherapeutics led to the development of pulsatile drug delivery systems which effectively delivered the drug at specified time. Diseases . Development and evaluation of a chronotherapeutic drug delivery system of torsemide. Songa Ambedkar Sunil, I; Nali Sreenivasa RaoI; Meka Venkata SrikanthI;.

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The chronotherapeutic approach to pharmaceutical treatment. In vitro buoyancy determination: MoxatagTM containing amoxicillin for use in antibiotic therapy.

Especially suited for active peptides and protein anabolic hormones [ 45 ]. In vitro dissolution studies [ 69 ]: Physicochemical parameters of CCT. In chronotberapeutic drug release study of Core tablet. Delivery by reservoir system with erodible or soluble barrier coatings: This may be in the form of beads, pellets or granules.

Oral tablet based Pharmaceutical tablet suitable to deliver the drlivery substance in subsequent and pre-determinable times US Gastroesophageal reflux disease, Pharmaceutical tablet dosage form, capable of delivering the active substance with three pulses to a pre-determinable release profile [ 42 ].

Chronotherapeutic Drug Delivery Systems

It was observed chfonotherapeutic the lag time increased as the concentration of the PEO in the outer coat increased. Reports suggests that more chances of heart attacks in the early morning hours ,high levels of cortisol levels ,blood drkg were also high early morning than drops off in the night [ 8 – 11 ]. Oral tablet based Multi-unit delivery system US Helminth infections, system provides pulsed delivery of a single drug or different drugs or drug formulations suited to the delivery of pharmacologically.


Study of biological rhythms and their mechanism is known as chronobiology. Didn’t get the message? We can position drug at a specific place or slow down its access to unwanted sites thus changing the time or extent of drug absorption in to stomach or intestine [ 33 – 35 ].

This ultimately reduces toxicity and improves patient compliance.

It may be used alone or in combination with thiazide diuretics. The sample was suitably diluted and analyzed for drug content by using UV-spectrophotometer Elico SL at A novel pulsatile release technology that consists of one immediate-release and two delayed-release components with the use of soluble and insoluble coatings.

The prepared core and compression coated tablets were subjected to in-vitro drug release studies in suitable dissolution media for 60 min and h respectively to assess their ability to provide the desired release. The friability test was carried out to evaluate the hardness and stability instantly in Roche Friabilator. With the incorporation of magnetic materials such as magnetite, iron, nickel, cobalt in to capsule or tablets by the external influence of magnetic field shown in Figure 5.

The result showed that batch 4, 5 and 6 had burst releases of 7, 8 and 9 hrs respectively. Drug release from magnetically induced pulsatile systems. Gastroesophageal reflux disease, Pharmaceutical tablet dosage form, capable of delivering the active substance with three pulses to a pre-determinable release profile [ 42 ]. The samples were filtered and analyzed spectrophotometrically at The tablet was introduced into the basket, and then lowered such that the lower end of the basket was 25 mm above the base of the beaker which was set to rotate at rpm.

The time at which the outer coating layer starts to rupture is called as lag time. The drug, diluents, disintegrant and binder were weighed for a batch of tablets as per formulae given in Table I. Torsemide is a pyridine-sulfonylurea type loop diuretic indicated for the treatment of hypertension and edema in congestive heart failure.


Chronotherapeutic Drug Delivery Systems | OMICS International

Each formulation showed a clear lag period before the drug release. Oral tablet based Pharmaceutical compositions US Infection of gram-positive and chronotherapwutic microorganisms, conventional film-coated tablets reduce the bioavailability of cefuroxime axetil and the invention overcomes this by control of systm film coat rupture time and use of a tablet core, which disintegrates immediately following rupture of the film coat [ 41 ]. This is done by sampling randomly and weighing 20 tablets and average weight is calculated.

The controlled release is achieved by constructing a multilayered tablet made of two basic key components; 1 hydrophilic polymers such as hydroxypropylmethycellulose HPMC and 2 surface chronnotherapeutic barrier layers. The advantage of this technique is that it is simply achieved by minor modification of existing equipment, inexpensive, is capable of physically separating two incompatible drugs within the same dosage form, allows taste masking of bitter drugs and is not hazardous to the environment, since it does not require the use of organic solvent Hadfield et al.

Select your language of interest to view the total content in your interested language. The major peaks for the pure drug were observed at It consists of a water insoluble capsule body filled with the drug and a cross-linked hydrogel plug which swells upon contact with dissolution medium or gastro intestinal fluids pushing it out of sytem capsules shown in Figure 3 [ 1516 ].

T excessive first pass metabolism, drug degrade in gastric acid medium in stomach, which results in bioavailability.